Solubility Enhancement of Embelin by Complexation with Beta Cyclodextrin

Abstract: Introduction: Embelin, a phytoconstituent obtained from Embelia ribes of the Myrsinaceae family, has anti-cancer, anti-inflammatory, anti-bacterial, anti-fertility, analgesic, antidiabetic, anti-depressant and wound healing activities. It is hydrophobic in nature leading to low bioavailability. Aim: The present study aims improve water solubility rate dissolution Embelin by complexation with β-cyclodextrin. Methods: Inclusion complexes were prepared physical mixture, kneading co-precipitation methods. Characterization was carried out Fourier-Transform Infrared (FT-IR) spectroscopy vitro study. Differential scanning calorimetry (DSC) Scanning electron microscopy (SEM) used analyze method. Antimicrobial studies against Staphylococcus aureus Escherichia coli colony counting Results: Phase showed forms complex β-cyclodextrin ratio 1:2. FT-IR confirmed DSC SEM also formation In that time release 50 % (t50) order 15 min, 30 60 min for coprecipitation, method mixture respectively. Complexes coprecipitation 2 log reductions number S. 1 reduction E. comparison Embelin. Conclusion: resulted largest percent drug content, enhanced aqueous antibacterial activity. Key words: β-cyclodextrin, complexes, Solubility, Co-precipitation